Research activities by the faculty

In order to promote research amongst various departments, the college has established distinct labs for undertaking research activities by faculty, UG, PG and Ph.D. students. The Research labs are established in the College premises under the direction of one or two faculty members. All the listed faculty members are registered supervisors of the University of Delhi.

S.No Research Lab In charge of Research Lab Department
1.

Anti-mycobacterial Drug Discovery Laboratory

(For Details: Click here)

Dr Urmi Bajpai

Biomedical Science

(For Details: Click here)

2.

Chemical Biology Laboratory

Dr Gagan Dhawan

Dr Seema Gupta

Biomedical Science

Chemistry

3.

Environmental Monitoring and Assessment Laboratory

Dr Charu Gupta

Botany

4.

Polymer Research Laboratory

Dr Sunita Hooda

Chemistry

5.

Research Laboratory of Inorganic Chemistry

Dr Vikrant Kumar

Chemistry

6.

Material Science Laboratory

Dr Amit Garg

Electronics

7.

Mathematics Research Centre Laboratory

Dr Chaman Singh and Dr Sadanand Prasad

Mathematics

8.

Sensing Materials and Devices Laboratory

Dr Arijit Chowdhuri

Physics

9.

Chandra Computational Physics Lab

Dr Subhash Kumar

Physics

10.

Insect Vector and Pests Laboratory

Dr Sarita Kumar

Zoology

11.

Microbial Technology Laboratory

Dr Monisha Khanna

Zoology

12.

Ciliate Biology Laboratory

Dr Ravi Toteja and Dr Seema Makhija

Zoology

13.

Embedded System and Robotics laboratory

Dr Amit Garg

Electronics

14.

Th!nk Laboratory: CUBE Laboratory in collaboration with HBCSE, Tata Institute of Fundamental Research, Mumbai

Exclusive student-run laboratory

Mentor:Dr Sarita Kumar

(For Details: Click here)

1. Antimycobacterial Drug Discovery Laboratory

This Lab is headed by Dr Urmi Bajpai

Research Interests:

In the ‘post-antibiotic era’, where high mortality rates are predicted due to multi-drug resistant (MDR) infections, urgent measures are required to be taken to manage the crisis. Several Mycobacterial spp. are leading pathogens associated with serious infectious diseases (tubercular and non- tubercular). The situation has worsened due to spread of MDR and extremely-drug resistant (XDR) strains, India having second highest MDR-TB burden in the world. Hence, there is pressing need to find alternate solutions and effective strategies to combat the menace of antimicrobial resistance.

In this context, the bactericidal activity of the lytic bacteriophages and their endolysins (and ectolysins) as drugs of bacteriophage origin are gaining attention. This path can lead to discovery of new molecular mechanisms and interactions, which could further pave the way for development of novel therapeutics and also contribute to basic research in the area. Mycobacteriophages infect mycobacterial hosts including fast dividing non-pathogenic M. smegmatis and clinically important M. tuberculosis, M. abscesses among others and are considered as reliable allies against the drug resistant infections. Due to the complex lipid rich cell envelop in mycobacterial species, mycobacteriophages have two different types of endolysins: LysinA and LysinB. The LysinA proteins are highly diverse in sequence and modular in nature. On comparing with standard-of-care antibiotics that often kill bacteria indiscriminately, phage and their derived lysins are not only extremely specific and hence do not harm the normal commensal microflora and they are also potent and effective against drug-resistant strains of pathogens. In my lab in the college, we isolate and purify lytic mycobacteriophages from the local environment using M.smegmatis as the bacterial host. Their morphological, physiological and genomic characterization is carried out to understand their diversity and unique features. We purify phage-derived endolysin enzymes as recombinant proteins and assay them for their biochemical and antibacterial activity.

Drug Discovery: Considering that a multi-target therapy is less likely to be rendered ineffective due to drug resistance than a single target therapy, we are studying Mur ligase (C-F) enzymes from Mycobacterium tuberculosis as the potential multi-targets since they share key structural features and similar catalytic mechanisms. Through Open Source Drug Discovery (OSDD) project on Multi-Target therapy for Tuberculosis, we have developed a One-Pot assay for MurA-MurF enzymes which catalyze the cytoplasmic steps in the peptidoglycan biosynthetic pathway and involve the synthesis of UDP-n-acetylmuramyl pentapeptide, a key precursor molecule required for the formation of the peptidoglycan monomeric building blocks. Through optimization of successive coupled enzyme assays using UDP-n-acetylglucosamine as the initial sugar substrate, we have reconstructed the pathway in vitro. The assay is biochemically characterized for screening of molecules that could disrupt multiple Mur enzymes and has been validated using known furan-based monocarboxylic compounds. Now, using MurB & MurE as the target proteins, in silico screening of FDA approved drugs for Drug Repurposing and anti-tubercular compounds is being done, to be followed by in vitro screening using the assay.

2. Chemical Biology Laboratory

This lab is headed by Dr Gagan Dhawan and Dr Seema Gupta

Research Interest:

Chemical Biology

  • Design and development of natural polymer based smart self-assembled nanostructures and hydrogel system for biomedical applications
  • Design and development of synthetic nano-vectors for delivery of biomolecules
  • Green synthesis and antimicrobial activity of silver nanoparticles
  • Understanding the molecular mechanism of potential antiviral strategy: UPR and autophagy crosstalk
  • Design, synthesis and biological evaluation of oxindole-based isoxazolines towards the analog synthesis of marine natural product Flustraminol B

Computational Biology

  • Use of open source tools integrating bioinformatics and cheminformatics for addressing complex problems in biology
  • Predicting the habitat of the bacteria and high-throughput data analysis for drug discovery using machine learning approach
  • Virtual screening of potential inhibitors against efflux pumps of microorganisms

PhD Scholars:

  • Ms. Indu Singh, BPharm, MPharm (DST Inspire Fellow)
  • Ms. Nishtha Agarwal, BSc, MS
  • Mr. Harekrushna Jena, BSc, MSc, MPhil

Publications

  • Materials Science & Engineering C, 2020, 107, 110284. [IF: 5.08]
  • Eur. J. Org. Chem (Wiley-VCH), 2019, 1, 150. [IF: 3.029]
  • Journal of Medicinal Chemistry (ACS), 2018, 61, 7785. [IF: 6.054]
  • Green Chemistry (RSC, London), 2018, 20, 3134. [IF: 9.405]
  • Artificial Cells, Nanomedicine, and Biotechnology (UK), 2018, 46(1), 1210. [IF: 4.462]
  • Green Chemistry (RSC, London), 2017, 19, 3851. [IF: 9.405]
  • J. Shanghai Inst. Tech. (Nat. Sci.) 2017, 17, 102.
  • Int. J. Biotechnology and Bioengineering, 2016, 10(4), 378.
  • DU Journal of Undergraduate Research and Innovation, 2015, 1(3), 20.
  • Nucleoside, Nucleotides and Nucleic Acids, 2015, 34(3), 149. [IF: 1.167]
  • Nucleic Acids Research (Oxford University Press, UK), 2012, 30 (23): e130. [IF: 11.147]

Book Chapter(s)

  • Basic and Clinical Virology, Austin Publishing Group, USA (2017). “Influenza pandemics and the associated bacterial infections”.
  • Pathogenicity and Drug resistance of Human Pathogens: Mechanisms and Novel Approaches, Springer-Nature, Singapore (2019). “Nanobiotechnology: Current and future perspectives in combating microbial pathogenesis”. (ISBN 978-981-329-449-3)

Research Projects

Innovation Project for Colleges Scheme of University of Delhi

  • Design, synthesis and biological evaluation of oxindole-based isoxazolines towards the analog synthesis of marine natural product Flustraminol-B (Aug, 2015-16)
  • Survey-based study to identify the health hazards associated with occupational exposure of chemically reactive dyes used by dyers to color the fabrics (May, 2012-13)

Innovation and Entrepreneurship Development Cell, DST, Government of India

  • Extraction of microbial enzymes from kitchen waste and preparation of Biological Detergent (Aug, 2015-16)
  • Design and development of gold nanoparticle based optical biosensor for protease sensing (July, 2014-15)
  • Use of open source tools integrating bioinformatics and cheminformatics for addressing complex problems in biology (Jan, 2013-14)

Dr Seema Gupta
Research Interest:

Chemical Biology

  • Green/Chemical synthesis of metals and metal chalcogenides nanoparticles
  • Green synthesis and antimicrobial activity of silver nanoparticles
  • Design, synthesis and biological evaluation of oxindole-based isoxazolines towards the analog synthesis of marine natural product Flustraminol B
  • Effective Delivery of Therapeutic Drugs: Design, Synthesis and Evaluation of Biodegradable Carriers
  • Publications

  • DU Journal of Undergraduate Research and Innovation, 2015, 1(3), 20.
  • Front. Bioeng. Biotechnol., 29 May 2020 | https://doi.org/10.3389/fbioe.2020.00504
  • Indian J Microbiol DOI 10.1007/s12088-020-00889-0
  • Book Chapter(s)

    • Content Contributor and Reviewer of the Global Edition of Chemistry,7/E by Mcmurry, Fay, Robinson

    Research Projects

    Innovation Projects for Colleges Scheme of University of Delhi

    • Survey-based study to identify the health hazards associated with occupational exposure of chemically reactive dyes used by dyers to color the fabrics (May, 2012-13)
    • Design, synthesis and biological evaluation of oxindole-based isoxazolines towards the analog synthesis of marine natural product Flustraminol-B (Aug, 2015-16)

    Projects Funded by Innovation and Entrepreneurship Development Cell, DST, Government of India

    • Formulation of biodegradable and low-cost Liquid detergent for laboratory glassware (2012-13)
    • Environment Management by Chemical Waste Treatment at the Source (2013-14)
    • Design and development of gold nanoparticle based optical biosensor for protease sensing (2014-15)
    • Extraction of microbial enzymes from kitchen waste and preparation of Biological Detergent (2015-16)

    3. Environment Monitoring and Assessment lab (EMAL)

    This Lab is headed by Dr Charu Khosla Gupta

    Research Interests:

    It addresses the key environmental issues of pollution and biodiversity conservation (through reproductive biology) besides air-pollution which is a very serious current environmental issue afflicting society. Assessment of the environmental quality of an area at a certain time is done with the help of biomarkers like chlorophyll, phenol, proline etc. as common environmental stress like air pollution leads to a change in the synthesis of bioactive molecules to resist the effect of stress on the plant. Research at EMAL encompasses looking at the effect of air pollutants, on various biomarkers in diverse species of flora in and around Delhi. As one of its thrust areas, EMAL is directly involved in monitoring and assessment of ambient air pollution, through collection of real-time data for different parameters of air pollution including particulate matter, carbon-dioxide, carbon monoxide, methane, VOCs etc. while offering proactive mitigation measures and suggesting ways and means that can effectively remove or reduce environmental pollution. Analysis of physico-chemical parameters of potable water samples in Delhi along with development of a low cost water purification system have also been undertaken. It is important for the society to be aware of the specific environmental problems at the local level and every responsible citizen has to adopt a way of life for sustainability which we promote by imparting Environment education to school and college students. Several undergraduate students have successfully completed short term research projects in the laboratory.

    Today, Environmental pollution has become an issue of serious concern for biodiversity, as it affects growth and reproduction of both plants and animals. Most severe effects of pollution are on seed germination, seedling survival, pollination, pollen viability, pollen-pistil interaction, stigma receptivity. Also availability of pollinators is considered crucial for reproductive success of a species, which is drastically being affected by Climate change. We are looking at all the above mentioned aspects along with the decoupling of plant-pollinator relationship, breeding systems and pollination mechanisms in medicinally important plants as a means of Biodiversity conservation. Investigation of genetic diversity in terms of gene flow, pollen flow and population structure in ethnobotanical species is also being explored. The research work carried out in EMAL has been awarded best presentation at two International conferences and has also the ‘Teaching Excellence award for Innovation’ by University of Delhi. Dr. Charu has been a Visiting Fellow at Jozef Stefan Institute, Ljubljana, SLOVENIA in October 2019 under aegis of INSA Bilateral Exchange Programme-2019 and has also been recognised as an Independent guide for Ph.D. by University of Delhi. Since the inception of the laboratory, we have completed a total of 06 Extramural research projects and published several papers in both National and International Journals along with several presentations in both National and International Conferences

    Contact: charukhoslagupta@andc.du.ac.in

    4. Polymer Research Laboratory

    This Lab is headed by Dr Sunita Hooda

    Research Interests:

    Synthesis, characterization and applications of various synthetic and modified natural polymers are carried out under various projects. Nano materials are also synthesized with biopolymers and graphene-oxide. Functionalized nanocomposite characterized by various instrumental techniques act as a super adsorbent for various types of dyes and toxic metal ions so find useful application in waste water treatment. These nanomaterials showed a promising application in wastewater treatment.

    In addition to this, different types of novel molecular probes are also synthesized using various heterocyclic compounds through covalent linkage. The structures of these probes are characterized by UV-Vis, Fluorescence, SEM, XRD and other related spectroscopic techniques. The molecular probes are then screened over assorted metal ion and selectivity observed towards different metal ions through the change of color in aqueous medium confirmed by UV or fluorescence signal and also supported by SEM and XRD results. The quenching in fluorescence spectrum is also observed with selective metal ions having high LOD, due to the loss of energy. This work produced a novel, simple and facile re-usable paper based chemical sensors, which can be used for naked eye evaluation of various metal ions.

    5. Research Laboratory of Inorganic Chemistry (RLIC)

    This Lab is headed by Dr. Vikrant Kumar

    Research interest:

    RLIC, a home of advanced and undergraduate research, aims to generate new concepts, methodologies, new materials and new reactions that drive the further evolution of chemistry.

    RLIC is highly dedicated to combine synthetic chemistry with biomedical research, so as to improve bio-distribution, specificity and biological recognition for cancer chemotherapy as well as the development of “Catalysts for Water Oxidation” addressing the challenge “Energy, especially renewable energy”.

    Contributions of RLIC are found in the areas:

    1. Bioinorganic Chemistry: Biomimetic Chemistry, Medicinal Chemistry, Nano-size clusters.
    2. Advanced materials: Bioactive Coordination Polymers – Approach towards making antimicrobial materials for advanced applications.
    3. Transitional Metal Complexes in Catalysis: Applications include the production of fine chemicals, pharmaceuticals, renewable energy source and waste-treatment processes.
    RLIC

    6. Research Activities in the Material Science Laboratory

    This Lab is headed by Dr Amit Garg

    Research interest:

    It is one of the research laboratories of the college which has the state of the art facilities to do contemporary research in tailoring of carbon based compounds and also synthesize hybrid combinations with other matching materials using nano techniques to create new materials with distinctive properties. The laboratory has a rich collection of basic equipments to carry out the synthesis of these materials through chemical route, facilities for thin film deposition using thermal evaporation as well as spinner, automated electrical characterization, high temperature annealing in ambient environment, clean room ambience through glove box, water purification membrane fabrication and gas sensing applications. Some of the key areas of research are briefly described as under-

    Graphene oxide(GO) is a form of heavily oxidized graphite and is synthesized by chemical exfoliation of graphite. It contains a number of functional groups of oxygen like epoxy (C-O-C), carboxyl (COOH), hydroxyl (OH) and carbonyl (C=O) species that are arranged on the basal planes and edges of the graphene oxide layers. We are engaged in tailoring the interlayer spacing of GO for their use in fabrication of water purification and desalination membranes. We are also carrying out systematic study exploring the gas sensing mechanism of GO films with different hybrids/nanocomposites for different gases like SO2, H2 etc. This study assumes importance since gas sensing properties of GO are critically influenced by the nature and abundance of edge sites wherein their concentration may be quite high in comparison to basal plane sites. The role of semiconducting metal oxide ZnO primarily as catalyst with GO films is being investigated in detail.

    Graphitic carbon nitride (g-C3N4) is one of the most promising and potential material known for its photocatalytic activity. It is the most stable allotrope of carbon nitride at ambient temperature. Due to the increase in population and industrialization, we are currently facing the global energy shortage and environmental problems. Our future energy needs require an abundant, renewable and green source of energy. This can be best met through solar energy which is renewable, free, abundant and clean fuel on earth. Thus huge attention has been focused to harness solar energy efficiently. The absorption edge of g-C3N4photocatalyst having a bandgap of 2.7 eV is around 460 nm which means it can absorb a part of visible sunlight. This makes it useful in various photocatalytic applications and fabrication of solar cells. Contemporary research works are focusing in this area of solar-energy conversion for increasing the harnessing efficiency of the solar energy. Photocatalysis is one such solution to our problem which is drawing worldwide attention. Photocatalysis utilizes solar energy to accelerate chemical reactions. It mainly includes water splitting for H2 production, reduction of CO2 for solar energy generation, degradation of pollutant and organic synthesis. As g-C3N4 is an excellent photocatalytic material due to its rich surface properties due to the presence of basic active surface sites, it exhibits high potential for solar energy conversion. We have recently initiated our research work focusing on the synthesis and appropriate doping of g-C3N4 for its enhanced photocatalytic activities. The material science research lab is adequately equipped to carry out their synthesis.

    Carbon nano-dots (or C-dots) are novel category of carbon materials having sizes in nm range around 5-10nm range. They are so called because of their zero dimension (0-D). C-dots have become a rising material because of their potential applications such as bio-imaging, optoelectronics, sensors, photocatalysts, water purification membranes etc. Carbon dots can also be used as a tool for sensitive ion detection. Carbon nano dots also have interesting antifouling, antimicrobial and surface chemistry properties which make them key material for their characteristic application in membrane formation and separation. The material science research lab is equipped to synthesize carbon nanodots through chemical route and decorate GO membranes with them to enhance their water purification and desalination abilities.

    7. Mathematics Research Centre Laboratory

    This Lab is headed by Dr Chaman Singh and Dr Sadanand Prasad

    Research Interests of Dr Chaman Singh:

    Dr. Chaman Singh is an Assistant Professor in Department of Mathematics, Acharya Narendra Dev College (University of Delhi). He is a distinguished researcher and has published many research papers in journals of International and National repute. His prime work is in the field of Optimization, Inventory Control and Supply Chain Management. He has authored/co-authored many books. He has also been the editor of many E-books. Dr. Singh also holds the post of Vice-presidentship of Meerut Chapter of Operational Research Society of India as well as of the Association for Advancement in Combinatorial Sciences. Dr. Singh also worked as an expert for the updation of Glossary of Mathematics coordinated by Commission for Scientific and Technical Terminology. Dr. Singh had been a fellow in Mathematics at Institute of Lifelong Learning, University of Delhi since November 2012 to January 2015, wherein he coordinated development of e-lessons for undergraduate students. He had also worked as Co-PI in Mathematics under NME-ICT a major project granted by MHRD. Presently, Dr. Singh is also an elected Member of Academic Council, University of Delhi since February 2017.

    Research Interest of Dr. Sada Nand Prasad:

    I have been doing research in Applied Mathematics and my field of specialization/interest is Dynamical Systems. I have worked on chaos theory and most of my research is on measuring chaos of different kinds of discrete maps/ models through Lyapunov Characterstic Exponent, Topological Entropy and Correlation dimension after getting the bifurcation diagrams leading to chaos. I have also used indicators of chaos like FLI, SALI, DLI etc. in some of my research papers. Apart from this I have also worked on Non Linear Dynamics and Space dynamics and few papers on restricted three body problem have been published in reputed journals. Currently I am working on generalised circular three body problem and on motion properties of the variable mass planetoid in the elliptical Sitnikov problem.

    8. Smart Materials Devices Laboratory (SMDL) @ ANDC

    This Lab is headed by Dr Arijit Chowdhuri

    Research Interests:

    Smart Materials and Devices Laboratory (SMDL) is established at Acharya Narendra Dev College (University of Delhi), Govindpuri, Kalkaji, New Delhi – 110 019, INDIA. It comprises of an active and dedicated research group headed by Dr. Arijit Chowdhuri, faculty in Department of Physics. Focussed towards processing of novel functional materials, SMDL is actively engaged towards development of smart materials having general, strategic and commercial applications. At SMDL the primary areas of research are concentrated towards the development of novel sensor materials and device prototypes using a variety of inputs for diverse applications including gas sensing, environmental and safety monitoring, diagnostics, point-of-care devices and wearable electronics. Some of the thrust areas of research at SMDL include - Electronic Nose for artificial olfaction, Integrated semiconductor gas/chemical sensors, Catalyst free sensors, Quartz Crystal Microbalance sensors, Surface Plasmon Resonance based gas/biosensing, Ambient air pollution detection and mitigation, water purification etc. Research collaborations at International and National level are actively promoted at SMDL and some of the recent collaborations include with scientists based in Australia, Norway, USA and Slovenia. In India SMDL has strong research collaborations and exchange programmes with National Physical Laboratory, Solid State Physics Laboratory besides EMDL at Department of Physics, University of Delhi. So far as at SMDL, 07 (seven) extra-mural research projects with an aggregate funding of Rs. 50 lakhs (approx.) from agencies including Department of Science & Technology and University of Delhi have been completed. Out of this one has been a bilateral project with Jozef Stefan Institute, Ljubljana, Slovenia. Since 2014 students have undertaken summer research projects at SMDL and 30 publications (02 - International Journals, 03 - National Journals, 10 - International conference presentations and 15 - National conference presentations) have resulted. As a result of introduction to cutting-edge areas of scientific research, focussed training on advanced equipments and acquisition of advanced hands-on skills at SMDL, since 2014 many students have been successful in garnering positions in reputed laboratories abroad on full scholarships to pursue higher education – Germany (5), France (1), Czech Republic (1), Italy (1), Taiwan (1), Netherlands (1). Research work carried out at SMDL has also been duly recognized and awarded – a) Best Innovative Idea award for DU Innovation project in 2015 and b) Recognition for Teaching Excellence and Innovation by University of Delhi.

    Contact Email: arijitchowdhuri@andc.du.ac.in

    9. Chandra Computational Physics Lab

    This Lab is headed by Dr Subhash Kumar

    Research Interests:

    It’s evident now that Sceintific investigation, apart from its theoretical and experimental methods has now acquired its third dimension- computational methods. Computational methods utilises data to discern the underlying patterns for making predictions or develop a scientifically cogent model. It has become one of the greatest tool for innovation and discoveries in the modern times. The Chandra Computational Physics Lab(CCPL) named after one of the greatest Indian Physicist and Nobel Laureate Subramanyam Chandrasekhar was established in the college to take this method of scientific discovery forward and acquaint the students and teachers into this dimension of scientific research. The Lab has a high speed workstation acquired from the funds of DU Innovation Project. While the core research emphasis of this lab uptil now has been Astronomy and Astrophysical Plasma, students have also completed research projects and dissertation which have been trans- disciplinary in nature. The lab remains open for all students and teachers to carry out research with students, requiring computational methods. The lab aims to make itself a hub for Data Science and Artificial Intelligence.

    10. Insect Pest & Vector Laboratory

    This Lab is headed by Dr. Sarita Kumar

    Research Interests:

    The Insect Pest and Vector laboratory was established in 2009 by Dr. Sarita Kumar. The laboratory is registered under Department of Zoology, University of Delhi for conducting research at doctoral and Post-doctoral level. The laboratory is primarily dedicated to explore different measures to control disease vectors (Aedes aegypti, Culex quinquefasciatus, Anopheles stephensi) and Crop pests (Helicoverpa armigera, Dysdercus koenigii). The students have worked diligently and consciously to develop broad-based ‘Learning Innovative Research Environment’. The laboratory is not limited to ‘Paper Presentation’ or ‘Lab Experiments’ but to “Develop alternate Eco-Safe Strategies for Mosquito/Insect Pest Control”.

    The laboratory has conducted quality research work. To-date, it has produced 42 research papers in peer-reviewed journals, 03 papers in e-books and more than 70 conference publications/presentations. Four students have already completed their Ph.D. from the laboratory. Currently, the laboratory has 06 scholars registered under University of Delhi for doctoral degree, 01 CSIR-Research Associate and 01 UGC-PDF.

    The laboratory also trains undergraduate students under the aegis of DST-IEDC, DBT Star Scheme, DU Innovation Project Scheme and ELITE Scheme of the college. Several UG students work through the year under the CUBE program of HBCSE, TIFR, Mumbai. Various projects have been completed and a few are ongoing.

    Completed Projects:

    03 DBT-Star Projects and 22 ELITE Projects

    (a) International:

    • ROER4D Sub-Project 2: “Research into Open Educational Resources for Development in Post-Secondary Education in the Global South”, University of Cape Town, South Africa

    (b) National

    • Major Research Project ‘A laboratory study on the larvicidal properties of certain botanicals against mosquito larvae-An alternative for mosquito control’ sanctioned by UGC (May 2009 – April, 2012)
    • Minor DST Entrepreneurship Project: ‘Identification and formulation of products from weed extracts exhibiting anti-mosquito potential’ (August, 2010 –July, 2011).
    • Minor DST Entrepreneurship Project: ‘Formulation of certain beneficial products from silkworm cocoon waste’ (October, 2011 – September, 2012).
    • Minor DST Entrepreneurship Project: ‘Evaluation of the beneficial properties and formulation of certain useful products from the waste peels of banana’ (April, 2013 – March, 2014).
    • Minor DST Entrepreneurship Project: ‘Formulation of Mehndi Remover Using Natural Products’ (Jan, 2016 – Dec, 2016).
    • DU Innovation Project: ‘Mobile healthcare: The future of health management in India- A Feasibility Study’; (2014-2015).
    • DU Innovation Project ‘Development of low-cost, robust, portable water purifier prototype with physical, chemical and biological filtration for field water disinfection and potable water generation in natural calamity afflicted zones with harsh conditions’; (2015-2016)

    Ongoing Project:

    DST Women Scientist Scheme-B Project: ‘Developing and documenting innovative practices for learning physics and biology through experimentation for children and young adults’. May, 2018-April 2021

    Sanctioned Project:

    ICMR-MERA Project: Attractive Toxic Sugar Bait (ATSB) methods to control mosquitoes in different regions of Delhi and NCR.

    11. Microbial Technology Lab

    This Lab is headed by Dr Monisha Khanna Kapur

    Research Interests:

    In this laboratory the research work is going on these two aspects:

    (1.) Characterization of bioactive compounds and detection of PKS and NRPS gene clusters from actinomycetes

    Actinomycetes are major producers of important biomolecules, accounting for 70-80% of secondary metabolites available commercially. Its various genera are known for the production of different classes of antibiotics. Microbial pathogens, however, are developing resistance to existing antibiotics. There is an urgent need to discover and develop new therapeutic compounds with unique modes of action. Structural analysis of biologically active secondary metabolites from actinomycetes leads to the discovery of new antibiotic compounds. GC-MS, LC-MS and 1H NMR are the widely used techniques for the structure elucidation of compounds. Extraction, purification and characterization of bioactive compounds from actinomycetes can fulfil the demand of the pharmaceutical industry. Polyketide synthase (PKS) and Non-ribosomal peptide synthetase (NRPS) are gene clusters which encode multimodular enzyme complexes responsible for the production of diverse bioactive compounds in actinomycetes. The presence of these gene clusters in actinomycetes indicates their biosynthetic potential for production of bioactive compounds. In our investigation we have characterized the bioactive compounds produced by Streptomyces sp. strains RI.24, RI.30, 196, 51, S.43 and SL.4 using GC-MS, LC-MS and NMR techniques. These strains were also screened for the presence of PKS and NRPS gene clusters using conserved domain-specific degenerate primers. Based on the bioactive compound profile and gene screening results, Streptomyces sp. strain 196 was selected as a potent candidate for further studies. Apart from antibacterial and antifungal activities, the compounds produced by strain 196 were also found to contain anticancer activity. In vitro studies were performed to analyse its anticancer potential, in obtained results it showed cytotoxicity against human lung cancer cell line (A549). Furthermore, whole-genome sequencing and genome mining of strain 196 genome was performed. In the genome of strain 196, complete PKS and NRPS gene clusters were predicted and characterized using bioinformatics tools. In future studies, the introduction of genetic modifications in the backbone of these gene clusters using domain swapping, deletion and insertion of domains, point mutations and cloning into suitable expression vector can produce novel bioactive compounds which may acts efficiently against resistant pathogens as well as infectious diseases.

    (2.) Identification of extracellular enzyme producing genes from Streptomyces spp. and their potential applications in various industries

    Streptomyces spp. secrete various types of extracellular enzymes that have numerous applications in industry and agriculture practices. The advancement of molecular strategies in place of the traditional microbiological approach has improved the production of enzymes on a large scale. Functional genomics, proteomics and other genetic techniques such as metabolic engineering and combinatorial biosynthesis have contributed to developing effective and stable enzymes to improve metabolic processes. Xylanase, chitinase, and cellulase are the major extracellular enzymes from Streptomyces spp. which play a huge role in various industries. Consortia of these enzyme-producing actinomycetes also showed an effective role in biodegradation and waste management. Cellulase and xylanase from actinomycetes are well known for converting lignocellulosic plant biomass into biofuels. In our study, we have done the whole genome sequencing and genome mining of Streptomyces sp. strain 130. In the genome of Streptomyces sp. strain 130, chitinase, xylanase and cellulase producing genes were found. In our current work, chitinases are being used as an antifungal agent to control the spoilage of food. Which may be very helpful to replace the use of chemical preservatives in food industry. Chemical additives and preservatives used in food industry directly harm the human health, so there is an urgent requirement to replace such chemical additives with effective extracellular enzymes.

    12. CILIATE BIOLOGY LABORATORY

    This Lab is headed by Dr Ravi Toteja (Officiating Principal) and Dr Seema Makhija

    Research Interests:

    Heavy metal induced oxidative stress response in spirotrich ciliates

    Heavy metal pollution of water is of major concern these days especially in developing countries like India. Anthropogenic sources, mainly mining and industrial activities, have contributed to substantial increase in heavy metal content in air and in many terrestrial and aquatic ecosystems. About 85 percent of the water pollution is caused by domestic and industrial sources. A wide range of contaminants are continuously introduced into the water and among these contaminants, heavy metals due to their toxicity, accumulation and non-degradable nature, constitute one of the most dangerous groups. Prolonged exposure to heavy metals such as cadmium, copper, lead and zinc disturb normal biological function and evoke cellular stress response. The research interest of our group is to examine how spirotrich ciliates respond to metal stress and to see the expression of heat shock proteins, metallothioneins and glutathione peroxidase gene under heavy metal stress. Moreover, the transcriptional activity of these genes are studied following heavy metals stress. The change in transcriptional activity can be used as a biomarker for monitoring the pollution level. Cellular response to heavy metals may also leads to generation of reactive oxygen species (ROS) which can be used as a tool in using whole cell ciliate as biosensor.

    Biodiversity of spirotrich ciliates

    We are also focusing on taxonomic description of freshwater ciliates by using morphological and molecular markers. We isolate and identify the ciliates from freshwater source in and around Delhi by studying its morphology, morphogenetic stages and using molecular markers like 18S rRNA gene, ITS1 and 2, histone gene etc.

    Extremophilic ciliates have been catalogued from a wide variety of regions such as hot water springs, caves, high altitudes etc. Ciliate communities have also been described from Biodiversity Hotspots such as Silent Valley Bioreserve and Eastern Himalayas. These have paid rich dividends in terms of endemism and distribution patterns.

    Fresh Water ciliate communities as bio-indicators of water pollution

    One of the present assignments deals with physic-chemical analyses of water and correlation with ciliate communities in water sources around the National Capital region.

    Assessment of soil quality by using ciliates as bio-indicators

    In our laboratory, presently ten undergraduate students are also working under DU-innovation project (AND-303). They are studying physico-chemical and biological analysis of soil samples collected from various regions in Delhi to assess the soil quality of these areas. Physico-chemical analysis of soil involves determination of soil texture, water holding capacity, pH, conductivity, nitrogen content, carbon content etc. and biological analysis involves identification of soil ciliates by live cell observations and staining techniques. The objective of this investigation is to correlate physic-chemical properties of the soil with the community structure of the ciliates.

    13. Embedded System and Robotics laboratory (INNOV8: The Robotics Society)

    Advisor: Dr. Amit Garg

    Research Interest:

    College established Embedded System and Robotics laboratory in 2012 to train students in this area. The training the students got under this laboratory has made them gain significant technical skill in this area. Three teams of Students were selected the National Level Robotics competition eYRC (e- Yantra Robotics Competition), 2014, a project sponsored by MHRD through the National Mission on Education through ICT (NMEICT) organized by IIT, Bombay. One of the teams made it to the finals out of the 3107 teams competing at the National level with 12428 students across the country. This initiative led to the establishment of InnoV8, the students’ Robotics Club that organizes workshops for the students to get training in Robotics. The uniqueness of this club is that already skilled students conduct workshops for their peers. They impart hands-on training to the students of Acharya Narendra Dev College to gain knowledge of robotics and sensors. They have organized several series of introductory workshop on Arduino to train the students and understand the basics of Arduino and simulate basic Arduino programs. The students have also developed their own version of the classic game Pacman, called Robo-Pacman, which was showcased during the departmental fest of Electronics department. It is part of E-YANTRA Lab initiative by IIT, Bombay. It has a rich treasure of Firebird robotics kits with wide range of sensors, wireless TX/RX zigbee, servo motors etc. It supports the skill enhancement paper on Robotics. Recently, two teams were selected in E-Yantra Robotics Competition 2019-20 organized by IIT Bombay. A total of 350 teams participated in this national competition. One of the teams consisting of Aman Tyagi ,Yash Varshney ,Anurag Saxena and Abhishek (Team Leader), all from B.Sc.(H) Electronics 2nd Year were amongst the 36 teams selected at national level based on the tasks given to them at each stage. The theme allotted to this team was “Survey and Rescue”.

    In addition, three more faculty members from Department of Computer Science are pursuing their research in the college. The area of their specialization is as follows:

    S.No Faculty Name Research Area
    1. Dr Sharanjit Kaur Data mining, stream clustering, graph mining and social network analysis.
    2. Dr Vibha Gaur Requirement Engineering, Quality Requirements, Users Trust, Software Development Models, Intuitionistic Fuzzy Logic and Fuzzy Cognitive Maps.
    3. Dr Chandrakant Samal Sensor networks, computer networks, opportunistic networks, Underwater Sensor Networks and Image Processing.

    Research Activities of Dr Sharanjit Kaur

    My research area include data mining, stream clustering, graph mining, social network analysis. Data mining is used to extract useful information/knowledge from the data using supervised and unsupervised techniques, where data is characterized by the features e.g. email data, iris data, friendship data etc. However fixed data has limited applications. With advancement in technology, it is feasible to capture data on-line e.g. weather data, stock data, sensor data etc. In other words, data continuously stream-in and thereby, keeps on changing or evolving with time. Need is to extract change in patterns, evolution etc. to have up-to-date knowledge about the prevailing trend, for which stream mining is used. However, in both cases, interaction among elements is not captured. There comes the role of graph mining where data is represented as network of nodes (entities) and links are simply interactions between them. Examples of network systems include metabolic pathways, proteinprotein interactions, food webs, the Internet, the World Wide Web, social interactions, and co-authorship, scientific collaboration and many more. Complex networks have attracted attention because of their ability to model a vareity of associations among entities in these networks. Analysis of networks is useful in understanding the structural features of the system. Applications of network analytics include identifying communities, detecting central nodes, monitoring influence propagation and many more. As size of social network is very large thereby making these analysis compute intensive. Recently, hierarchical graph decomposition is explored for effective and scalable network analysis. Currently, multi-layered networks (MLN) are also being studied for analysing data from multiple perspectives to infer meaningful knowledge. E.g. in scientific networks, the need is to identify scientists who are not only working on same discipline and co-authoring articles but are affilated to different organizations or may have presented papers/talks at same places. Other examples of MLN include genes correlated networks, social (friendship) networks etc.

    Research Activities of Dr Chandra Kanta Samal

    Dr. Chandra Kanta Samal received the M. Tech. and Ph.D. Degrees in Computer Sciences from the Jawaharlal Nehru University, School of Computer and Systems Sciences, New Delhi, India and M.C.A from the Utkal University, Department of Computer Science and Application, Vani Vihar, Bhubaneswar, Odisa, India. He is presently working as Assistant Professor Department of Computer Science, Acharya Narendra Dev College (ANDC), University of Delhi, India. He has published 25 research papers International Journals and Conferences, attended many International conferences and Session Chaired, paper reviewer of three international journals and many conferences. His current research interests include wireless ad-hoc networks, sensor networks, computer networks, opportunistic networks Underwater Sensor Networks and Image Processing.

    Nature observational studies and monitoring of biodiversity

    In addition, the Green stretch of ANDC campus allows nature observational studies and monitoring of biodiversity in the college. This initiative is taken by one of our faculty member from the Department of Biomedical Science, Dr Rajesh Choudhary. He is well supported by one of his lab member, Mr Vinesh Kumar The college is located in the midst of a densely urbanized area of Delhi. However, numerous herbs and trees which the campus harbours provide suitable habitat for breeding and halt for several species of arthropods and birds. This provides an opportunity to monitor movement of animals in and out of the campus and perform several observational ecological studies. Results of preliminary studies performed on birds and butterflies are encouraging. In this regard, the college has also dedicated a patch of vegetation which is rich in biodiversity.

    Brochure_Butterflies
    BIONOTES
    Nature Observational Studies in News